The operating system is not presently configured to run this application
By Lorren Zemke, Director of Professional ServicesFriday, July 22, 2016
We just installed Excel 2016 and when we open a SmartConnect map that uses Excel as a Data Source we receive the error “The operating system is not presently configured to run this application.”
This is due to running Office applications in compatibility mode or by a corrupted installation of Microsoft Office. Please refer to this link and this one for resolutions. If the Microsoft Office Repair does not work then it will require a removal of all Office products and reinstall of Office 2016.