We just installed Excel 2016 and when we open a SmartConnect map that uses Excel as a Data Source we receive the error “The operating system is not presently configured to run this application.”

This is due to running Office applications in compatibility mode or by a corrupted installation of Microsoft Office. Please refer to this link and this one for resolutions. If the Microsoft Office Repair does not work then it will require a removal of all Office products and reinstall of Office 2016.

If you just started experiencing this error in September 2020, this is due to an Office update released early in September that breaks the Excel ODBC drivers.   The link to the new article is here:  The operating system is not presently configured to run this application.